Seroprevalence and Associated Risk Factors of Hepatitis B Virus Infection in Bouaké, Côte D´Ivoire
A. Diarrassouba *
Department of Fondamental and Bioclinical Sciences, Laboratory of Bacteriology-Virology, Alassane Ouattara University of Bouaké, Côte d´Ivoire and Bacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
S. F. Toure
Bacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
Y. L. C. Karidioula
Bacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
A. M. Konan
Bacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
A. Traoré
Bacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
P. Monemo
Department of Fondamental and Bioclinical Sciences, Laboratory of Bacteriology-Virology, Alassane Ouattara University of Bouaké, Côte d´Ivoire andBacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
E. A. Anoh
Bacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
S. Karidioula
Bacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
J. O. N. Tadet
Bacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
S. D. Adon
Bacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
R. Asse
Bacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
C. Akoua- Koffi
Department of Fondamental and Bioclinical Sciences, Laboratory of Bacteriology-Virology, Alassane Ouattara University of Bouaké, Côte d´Ivoire and Bacteriology-Virology Laboratory, Bouaké Teaching Hospital, Côte d´Ivoire.
*Author to whom correspondence should be addressed.
Abstract
Aim: Determine the prevalence of serological markers and identify risk factors associated with Hepatitis B Virus (HBV) infection in patients screened at the Bouake teaching hospital.
Study Design: Retrospective cross sectional study was conducted
Study Site and Period: Bacteriology-Virology Laboratory/Bouake teaching hospital, Côte d´Ivoire, from April 2016 to January 2018.
Methodology: In all 1076 study participants, venous blood sample was collected and screened for HBV surface antigen (HBsAg) and antibody against HBV core antigen (anti-HBc), by electrochemical-luminescence following the manufacturer protocols. Additionally, questionnaires were used to collect information regarding sociodemographic variables and possible risk factors for hepatitis B infection. Data were processed and analyzed using EPI INFO 7 software.
Results: A total of 1076 participants were included in this study with a median age of 30.0 years (range: 3 months; 82 years). Of which, 514 (48%) were female and 562 (52%) were male with female / male ratio 1.09. HBsAg was detected in 24,3% of participants and 82 1 (76,3%) were exposed to the risk of HBV infection (anti-HBc positive). High rate of HBV infection was detected in male (27.93%) (p=0.003). The age group of 15–45 years were more infected (27.18%) (p<0.0001). The detection rate of HBe antigen (HBeAg), anti-HBe and anti-HBc (total antibodies) were respectively 12%; 86% and 7%. Of 938 participants who were not vaccinated against HBV, 240 (25.58%) were HBsAg-positive. HBV vaccine uptake was protective against HBV infection (AOR =0.580; 95% CI 0.359-0.938; p=0.024).
Conclusion: The rate of carriage of HBs antigen was higer than national rate, which confirms that Bouake is a highly endemic area for HBV infection. Vaccination against Hepatitis B virus is the only way to prevent and to fight effectively against this infection. It is therefore important to encourage the screening and vaccination in the general population.
Keywords: Hepatitis B, HBsAg, anti-HBc, Bouake, Côte d’Ivoire