Evaluation of Non-response to Hepatitis B Vaccines in Individuals Over 15 Years in the Centre Region of Cameroon: A Cross-sectional Study
Justin Olivier Essindi
Department of Microbiology, Faculty of Science, The University of Yaoundé I, Cameroon.
Jacky Njiki Bikoï
Department of Microbiology, Faculty of Science, The University of Yaoundé I, Cameroon.
Carole Stéphanie Sake
Department of Microbiology, Faculty of Science, The University of Yaoundé I, Cameroon.
Donatien Serge Mbaga *
Department of Microbiology, Faculty of Science, The University of Yaoundé I, Cameroon.
Arnaud Franck Elang
Department of Microbiology, Faculty of Science, The University of Yaoundé I, Cameroon.
Chris André Mbongue Mikangue
Department of Microbiology, Faculty of Science, The University of Yaoundé I, Cameroon.
Aicha Ngoutane
Department of Microbiology, Faculty of Science, The University of Yaoundé I, Cameroon and Institute of Medical Research and Medicinal Plant Study, Yaoundé, Cameroon.
Alexandra Emmanuelle Membangbi
Department of Microbiology, Faculty of Science, The University of Yaoundé I, Cameroon.
Sabine Aimée Touangnou-Chamda
Department of Microbiology, Faculty of Science, The University of Yaoundé I, Cameroon.
Sara Honorine Riwom Essama
Department of Microbiology, Faculty of Science, The University of Yaoundé I, Cameroon.
*Author to whom correspondence should be addressed.
Abstract
Background: To investigate the risks factors associated to the non-response of hepatitis B (HB) immunization in participants over the age of 15 years.
Methods: From October 2020 to December 2021, data were collected from individuals aged over 15 years who receive at least one dose of vaccine. An algorithm consisted of three (03) tests researching anti-HBs whose detectability threshold was 10 IU/L and anti-HBc.
Results: A total of 330 participants were included in this study, among which 158 received three doses of vaccine, of these 83.59% and 6,6% were found positive respectively to anti HBs and anti-HBc. We noted that, age [30 – 40] years [OR= 2.41; CI at 95% (1.24 – 4.80)]; single status [OR=10.80; CI at 95% (1.78 – 114.8)], obesity [OR=2.99; CI at 95% (1.13 – 7.27)], alcohol [OR=10.80; CI at 95% (1.78 – 114.8)]; HEPATITIS vaccine [OR=3.40; CI at 95% (1.24 – 9.10)] were associated with non-response to hepatitis B vaccines.
Conclusion: Non-response to hepatitis B vaccination has been influenced by several risk factors that should be considered during the vaccination process.
Keywords: Anti-HBc, anti-HBs, hepatitis B vaccines