Bacteriological Profile and Antibiotic Resistance of Uropathogens Bacteria in Pregnant Women in Conakry, Guinea
Abdoulaye Makanéra *
Biomedical Laboratory of the China-Guinea Friendship Hospital, Kipé, Cité des Médecins, Ratoma Commune 30BP710 Conakry, Republic of Guinea and Faculty of Health Sciences and Techniques, Department of Medicine, Gamal Abdel Nasser University of Conakry, BP1147, Republic of Guinea.
Taliby Dos Camara
Faculty of Sciences, Department of Biology, Gamal Abdel Nasser University of Conakry, BP 1147, Republic of Guinea.
Fatoumata Koné
Faculty of Medical and Paramedical Sciences, Department of Pharmacy, Kofi Annan University of Guinea, Republic of Guinea.
Moise Koi Koivogui
Anastasis Health Center of Nongo, Ratoma Commune, Conakry, Republic of Guinea.
Mariam Condé
Biomedical Laboratory of the China-Guinea Friendship Hospital, Kipé, Cité des Médecins, Ratoma Commune 30BP710 Conakry, Republic of Guinea.
Oumar Souaré
Biomedical Laboratory of the China-Guinea Friendship Hospital, Kipé, Cité des Médecins, Ratoma Commune 30BP710 Conakry, Republic of Guinea.
Bintou Konaté
Biomedical Laboratory of the China-Guinea Friendship Hospital, Kipé, Cité des Médecins, Ratoma Commune 30BP710 Conakry, Republic of Guinea.
Alpha Oumar Barry
Biomedical Laboratory of the China-Guinea Friendship Hospital, Kipé, Cité des Médecins, Ratoma Commune 30BP710 Conakry, Republic of Guinea.
Kounady Fatoumata Camara
Biomedical Laboratory of the China-Guinea Friendship Hospital, Kipé, Cité des Médecins, Ratoma Commune 30BP710 Conakry, Republic of Guinea.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Urinary tract infections (UTIs) represent one of the most common bacterial infections worldwide, particularly affecting pregnant women. Objective: The aim of the present study was to describe the bacteriological profile and antibiotic susceptibility patterns of uropathogenic bacteria isolated from pregnant women consulting for UTIs in Conakry, Guinea. Methods: A six month cross sectional investigation was carried out from April to September 2023. Bacterial cultures of 105 samples were done on different solid media. Bacterial identification and antibiotic susceptibility were performed by API kits and the VITEK-2 Compact system.
Results: The age group of 18 to 25 years was predominant. Based on socio-professional characteristics, seamstresses were in the majority, followed by housewives. Multi-gesture women were predominant (41.9%), followed by Primigestrous women (39%). Urinary tract infections were more frequently observed in the second trimester of pregnancy (52.4%). Approximately 26.7% of women were on antibiotics while only 4.8% used herbal infusion. Eighty one samples (77.1 %) yielded bacterial growth. The isolates included 48% (=39/81) Gram negative bacilli and 52 % (=42/81) Gram positive cocci, belonged to 9 different bacterial species. Escherichia coli was the most frequently isolated (34.6%), followed by Staphylococcus lentus (29.7%), Staphylococcus xylosus (11.1%) and Staphylococcus aureus (9.9%). Gram negative bacilli were mostly sensitive to Cefoperazone + sulbactam (94.87%), piperacillin/ tazobactam (84.6 %), imipenem (79.5 %), and amoxicillin/clavulanate (71.8 %), but highly resistant to ampicillin (87 %), cefotaxime (97 %), and cefixime (85 %). Gram positive cocci showed marked resistance to tetracycline (95 %), gentamicin (62 %), and tobramycin (74 %), but they were sensitiveto but sesitive to Pristinamycin (83.33%), Quinipristine/Dalfopristine (80.95%), Nitrofurantoin (73.8%). Conclusion: These results highlight multi-resistance to antibiotics of uropathogenic germs during pregnancy in Conakry, thus requiring continuous monitoring of antibiotic resistance through rational use of antibiotics during pregnancy in Guinea.
Keywords: Pregnant women, urinary tract infections, antibiotics resistance, bacteria, Conakry