Description of the First Case of Mycobacterium tuberculosis Beijing Strain Isolated in Cameroon
Francioli Koro Koro *
Department of Biochemistry, Faculty of Sciences, University of Douala, Douala, Cameroon and Mycobacteriology Service, Reference Laboratory of NTP, Centre Pasteur of Cameroon, Cameroon-Pasteur Institute International Network, Yaoundé, Cameroon
Joseph Rodrigue Foe Essomba
Mycobacteriology Service, Reference Laboratory of NTP, Centre Pasteur of Cameroon, Cameroon-Pasteur Institute International Network, Yaoundé, Cameroon
Leslie Kaiyven Afi
Mycobacteriology Service, Reference Laboratory of NTP, Centre Pasteur of Cameroon, Cameroon-Pasteur Institute International Network, Yaoundé, Cameroon
Yannick Kamdem Simo
Mycobacteriology Service, Reference Laboratory of NTP, Centre Pasteur of Cameroon, Cameroon-Pasteur Institute International Network, Yaoundé, Cameroon
Félix Fotso Piam
Mycobacteriology Service, Reference Laboratory of NTP, Centre Pasteur of Cameroon, Cameroon-Pasteur Institute International Network, Yaoundé, Cameroon
Mbe Jean Romain
Mycobacteriology Service, Reference Laboratory of NTP, Centre Pasteur of Cameroon, Cameroon-Pasteur Institute International Network, Yaoundé, Cameroon
Jurgen Noeske
German International Cooperation (GIZ), Yaoundé, Cameroon
François-Xavier Etoa
Department of Biochemistry, Faculty of Sciences, University of Douala, Douala, Cameroon
Sara Irène Eyangoh
Mycobacteriology Service, Reference Laboratory of NTP, Centre Pasteur of Cameroon, Cameroon-Pasteur Institute International Network, Yaoundé, Cameroon
*Author to whom correspondence should be addressed.
Abstract
Aims: Beijing remain the most M. tuberculosis lineage distributed and associated to multidrug resistance known worldwide. Its detection in a young person urge to make a large molecular epidemiology study in the concerned region since this can significantly impact tuberculosis (TB) control and vaccine strategies development.
Presentation of Case: In this study, we described the first case of M. tuberculosis Beijing strain isolated from a 20 years old girl in Cameroon. This strain was resistant to Isoniazid, Rifampicin, Streptomycin and Ethambutol. Spoligotyping and MIRU/VNTR genotyping analysis showed that the strain belonged to SIT1. The patient responded well to 12 months drug therapy of 4 KmGfxPtoHCfzEZ / 8 GfxPtoCfzEZ; although she was probably contaminated by her elder sister who died from TB few months before. This case may traduce a transmission event in Cameroon.
Conclusion: This was the first study that isolated M. tuberculosis Beijing lineage in Cameroon and showed the importance to purchase a large study in the concerned regions.
Keywords: M. tuberculosis, Beijing strain, Cameroon, MIRU/VNTR genotyping, multi drug resistance, spoligotyping