Study on Association of Recent and Past Chlamydophila pneumoniae Infection with Classic Multiple Sclerosis
Hamidreza Honarmand
Department of Microbiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Masoumeh Ahmadi Jalali Moghadam *
Cellular and Molecular Research Center, Faculty of Midicin, Guilan University of Medical Sciences, Rasht, Iran
Hamidreza Hatamian
Department of Neurology, Poursina hospital, Guilan University of Medical Sciences, Rasht, Iran
Ali Roudbary
Department of Neurology, Poursina hospital, Guilan University of Medical Sciences, Rasht, Iran
*Author to whom correspondence should be addressed.
Abstract
Aims: We conducted this study to determine if there is any correlation between Classical Multiple Sclerosis and Chlamydophilia pneumoniae infection by ELISA (IgM, IgG, IgA).
Study Design: cross sectional study
Place and Duration of Study: The present study was performed in the Department of Microbiology, Guilan University of Medical Sciences between April 2012 and April 2013
Methodology: Chlamydophila pneumoniae infection certified by ELISA in patients (n=46) and control (n=46) using commercial assays (anti- C. pneumoniae IgG, anti- C. pneumoniae IgM, and anti- C. pneumoniae IgA kits). Data were analyzed by using four statistical tests (Pearson chi square, Kendall's tau, and Spearman's rho).
Results: Seropositivity to anti- C. pneumoniae IgG was seen less frequently in patients versus controls (69.0% versus 81.4%; P=0.187). Seropositivity to anti- C. pneumoniae IgA was also observed less frequently in patients than in controls (7.2 % versus 11.6%; P= 0.479).However anti- C. pneumoniae IgM antibodies were seen more often in classical multiple sclerosis patients than it was in controls ( 11.9% versus 2.3%; P= 0.085).
Conclusion: We concluded that recent or past C. pneumoniae infection has no correlation in initiation or protection of CMS.
Keywords: Chlamydophila pneumonia, multiple sclerosis, anti- C. pneumoniae IgG, anti- C. pneumoniae IgM, and Anti- C. pneumoniae IgA