Lactose Fermenting Salmonella Spp in Akure: Antibiotic Resistance Patterns and Resulting Clinical Implications
O. I. Afolami
Department of Microbiology, Federal University of Technology, P.M.B. 704, Akure, Ondo State, Nigeria.
A. K. Onifade *
Department of Microbiology, Federal University of Technology, P.M.B. 704, Akure, Ondo State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
A total of 200 clinical and water samples from Akure metropolis were subjected to bacteriological analysis, of which 37 isolates of lactose fermenting Salmonella were obtained; Antibiotic sensitivity tests were carried out on the lactose fermenting isolates of Salmonella spp obtained from the samples. From the results, it was discovered that all the lactose fermenting isolates of Salmonella showed multiple antibiotic resistances (multidrug resistance) to the different broad spectrum antibiotics used at varying standard inhibitory concentrations. This conducted study gave an insight into the rising incidence of relapsing salmonellosis due to multiple antibiotic resistant strains of lactose fermenting Salmonella in the Akure metropolis, provided a scientific explanation to the modified feeding patterns as seen in the Salmonella isolates that can utilize lactose sugar due to their genetic modifications and critically evaluated the resulting clinical implications of these residual multiple antibiotic resistant- lactose fermenting Salmonella isolates obtained from the metropolis between July and October 2014 during which this research was conducted.
Keywords: Lactose fermenting Salmonella, multiple antibiotic resistances, clinical implications, enteric relapsing Salmonellosis, genetic modifications